Each capsule contains:
Sulfamethoxazole 400 mg
Trimethoprim 80 mg

Each 5 mL contains:
Sulfamethoxazole 200 mg/400 mg
Trimethoprim 40 mg/80 mg

COTRIMOXAZOLE is supplied in oral capsules containing 80 mg of trimethoprim and 40 mg of sulfamethoxazole. The usual adult dose is 2 capsules every 12 hours for 10 to 14 days for mangement of mast infections. Larger quantities have been gevin in special circumstances in patients with lessions or life-threatening disease. The following dosage should be obscured in patients with renal insufficiency : Creatinine clearance over 30 mL per minute. The usual dosage schedule ; clearance 0f 15 to 30 mL per minute, two capsules every 24 hours. If the clearance is less than 15 mL per minute,the presentation should not be administered.

In granules for oral suspension containing 40 mg of trimethoprim and 200 mg of sulfamethoxazole. For children 6-12 years, 1-2 teaspoonful (5-10 mL), 2-5 years, ½ -1 teaspoonful (2.5-5 mL),less than 2 years,½ teaspoonful (2.5 mL) to be taken twice a daily. Since there as a yet insufficient data, the combination must be used with great caution in pregnant patients,infants under 1 month of age –use is contraindicated since sulfonamides may cause kernicterus in neonates. In addition,because of the altered disposition of sulfomethoxazole and trimethoprim in neonates and older infants,the fixed ratio (1:5)combination is innappropriate.

COTRIMOXAZOLE remain very useful for the management of most patients with uncomplicated infection of the lower urinary tract. Sulfonamides should be reserved for the management of acute and chronic cystitis,chronic infection of the upper urinary tract,and asymptomatic biliuria. Since acute cystitis is most often cause by E. Coli or Pr.mirabilis,the sulfonamides are highly effective.COTRIMOXAZOLE is effective in the management of acute gonococcal urethritis in both men and woman. It appears to have beneficial effect in acute and chronic prostitis and prostatic abscess. Pulmonary infections of various types have been treated with COTRIMOXAZOLE.

Capsules 400 mg/80 mg available in box of 100 Capsules
Suspension 200 mg/40 mgx 60 mL bottle
400 mg/80mg x 60 mL bottle